Schedule of Classes
This table provides the current schedule of classes for EPI 5344. For session-specific readings, you should consult the separate material given here. The last column of the table provides links to any files which relate to the session (e.g. Power Point slides, if any).
| # | Date | Topic | Page Ref in Allison,2nd edition) |
PPTX Files | PPF Files |
|---|---|---|---|---|---|
| 1 | March 6 | Introduction to Survival methods. Incidence proportion vs. incidence rate. The hazard function. Censoring. Risk set. Actuarial and Kaplan Maier methods. Confidence intervals. | p 1-38, 49-59 |
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| 2 | March 13 |
Estimation of the hazard function. Smoothing methods. Concept of proportional hazards. Non-regression approaches to comparison of groups. Test for trend. |
p 29-70 |
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| 3 | March 20 | Introduction to Maximum Likelihood methods. Parameter estimation. 95% confidence interval estimation. Parametric regression models, focusing on exponential and piecewise exponential models. | p 71-80, 87-95, 98-103, 112-116 |
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| 4 | March 27 | COX Models I. Introduction of the Cox model. Estimation of parameters. Ties. Types of predictor variables and modeling approaches. Interpretation of coefficients. HR variability by 'predictor' variables vs. 'over time'. | p 125-153 |
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| 5 | April 3 | COX Models II. Application of Cox models to confounding and effect modification. Dose response effects and non-linearity issues. Time dependent covariates. Numerical problems. |
p 153-172 |
A: Confounding | A: Confounding |
| 6 | April 10 | COX Models III. Non-proportional hazard Cox models. Testing of proportional hazards assumption. Estimating survival curves from Cox models. Interval censoring, left truncation. Approaches for discrete-time models | p 172-193 |
Assignments
The details of the course evaluation methods and assignments are discussed here. The deadline dates for each assignment are:
Assignment #1:March 20, 2012
Assignment #2: April 27, 2012
